Darier and Ferrand’s Dermatofibrosarcoma: About 10 Cases and Review of the Literature

Summary: Darier-Ferrand dermatofibrosarcoma (DFS) is a rare, locally aggressive mesenchymal skin tumor characterized by slow growth and a high potential for local recurrence. Its diagnosis is based on histology and immunohistochemistry, including CD34 positivity. We report a descriptive retrospective study conducted in the plastic surgery department of Ibn Sina University Hospital in Rabat, including ten patients operated on for DFS between January 2019 and December 2022. Epidemiological, clinical, histological, therapeutic, and evolutionary data were analyzed. The majority of patients had a tumor located on the trunk or limbs. All underwent wide surgical excision with appropriate reconstruction. The local recurrence rate was low (1 case). These results are consistent with data from the literature and highlight the importance of safety margins. Wide excision remains the cornerstone of DFS treatment. Early diagnosis, multidisciplinary care, and prolonged follow-up are essential. Access to modern techniques such as Mohs surgery or targeted therapies, as well as molecular screening, could significantly improve prognosis.