Effacts of Goko Herbal Cleanser Mixture on Haematological Parameters in Wistar Rats

Abstract: Background: Goko herbal cleanser mixture is a popular herbal preparation used in Nigeria and other African countries for microbial infections and diseases management. Its bio-active compounds influence several biological processes which has also raises some safety concern. The present study is aimed at determining the impact of Goko herbal cleanser mixture on hematological parameters of Wistar rats. Methods: An experimental laboratory design method was adapted in the study, which involved Twelve Wistar rats, grouped into control, medium-dose (0.5ml/kg) and high-dose (1ml/kg) categories, with Goko cleanser herbal mixture administered over 21 days. Hematological parameters were analyzed using hematology analyzer method and data were evaluated statistically. Result: The data revealed that moderate doses of Goko cleanser herbal mixture improved RBC and platelet counts, potentially supporting erythropoiesis and thrombopoiesis. However, higher doses of Goko cleanser herbal mixture reduces the RBC quality, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH), which suggest potential risk of toxicity. Conclusion: Goko herbal cleanser mixture elicit a dose-dependent impacts on erythropoiesis and thrombopoiesis, highlighting the need for careful dosage regulation to maximize therapeutic outcome and reduces the adverse effects of high doses.